Innovative pharmaceutics and biotechnology paradigms translating advances in chemistry
A Fernandez, T R Sosnick and A Colubri (2002) Dynamics of hydrogen bond desolvation in folding proteins. Journal of Molecular Biology 321, 659-676
A Fernandez, J Kardos, R L Scott, Y Goto and R S Berry (2003) Structural defects and the diagnosis of amyloidogenic propensity. Proceedings of the National Academy of Sciences USA 100, 6446-6451
A Fernandez and H A Scheraga (2003) Insufficiently dehydrated hydrogen bonds as determinants of protein interactions. Proceedings of the National Academy of Sciences USA 100, 113-118
A Fernandez and R L Scott (2003) Adherence of packing defects in soluble proteins. Physical Review Letters 91, 018102
A Fernandez (2004) Keeping dry and crossing membranes. Nature Biotechnology 22, 1081-1084
A Fernandez, K Rogale, R L Scott and H A Scheraga (2004) Inhibitor design by wrapping packing defects in HIV-1 proteins. Proceedings of the National Academy of Sciences USA 101, 11640-11645
A Fernandez and R S Berry (2004) Molecular dimension explored in evolution to promote proteomic complexity. Proceedings of the National Academy of Sciences USA 101, 13460-13465
A Fernandez et al. (2007) An anticancer C-kit kinase inhibitor is re-engineered to make it more active and less cardiotoxic. Journal of Clinical Investigation 117, 4044-4055
A Fernandez, X Zhang and J Chen (2008) Folding and wrapping soluble proteins: Exploring the molecular basis of cooperativity and aggregation. Progress in Molecular Biology and Translational Science 83, 53-88
A Fernandez and J Chen (2009) Human capacitance to dosage imbalance: coping with inefficient selection. Genome Research 19, 2185-2192
A Fernandez and M Lynch (2011) Nonadaptive origins of interactome complexity.
Nature 474, 502-505
A Fernandez (2012) Epistructural tension promotes protein associations.
Physical Review Letters 108, 188102
Ariel Fernandez (2014) Synergizing immunotherapy with molecular-targeted anticancer treatment. Drug Discovery Today, in press.